This therapy was  developed in the early 1980’s by Dr. Thomas T. Aoki  while he was head of the Metabolism Section of the Joslin Diabetes Center in Boston  and Associate Professor at Harvard Medical  School .  

  The MAT®  program consists of a once-a-week treatment session of  6 hours of programmed intermittent intravenous insulin therapy, together with oral glucose. This outpatient intravenous insulin therapy provides a more effective insulin signal than can be achieved by other methods of insulin administration.

  The treatment  session uses a complex proprietary methodology under the direction of a physician in a healthcare setting. Patients spend most of the time in big lounge chairs, reading, watching TV, doing homework from school or  business, but are able to walk around as needed.      

  The remainder of the week the patient follows American Diabetes Association (ADA) or American Association of Clinical Endocrinologists (AACE)  recommended therapy.

   The patient and physician work in partnership to optimize health with attention to diet, exercise, and treatment of other medical problems such as hypertension.

   Patients and physicians should be very wary of companies or persons who claim to offer this therapy, but offer it under names other than  metabolic activation therapy.